A survey of acute and chronic heroin dependence in ten inbred mouse strains: evidence of genetic correlation with morphine dependence
G Klein, A Juni, AR Waxman, CA Arout… - Pharmacology …, 2008 - Elsevier
Heroin and morphine exposure can cause physical dependence, with symptoms
manifesting during their withdrawal. Inter-individual differences in symptom frequency during
morphine withdrawal are a common finding that, in rodents, is demonstrably attributable to
genotype. However, it is not known whether inter-individual differences characterize heroin
withdrawal, and whether such variation can be similarly influenced by genotype. Therefore,
we injected mice of ten inbred strains with acute and chronic heroin doses and compared …
manifesting during their withdrawal. Inter-individual differences in symptom frequency during
morphine withdrawal are a common finding that, in rodents, is demonstrably attributable to
genotype. However, it is not known whether inter-individual differences characterize heroin
withdrawal, and whether such variation can be similarly influenced by genotype. Therefore,
we injected mice of ten inbred strains with acute and chronic heroin doses and compared …