[HTML][HTML] Inflammatory cytokines determine the susceptibility of human CD8 T cells to Fas-mediated activation-induced cell death through modulation of FasL and c …

A von Rossum, R Krall, NK Escalante… - Journal of Biological …, 2011 - ASBMB
The nature of inflammatory signals determines the outcome of T cell responses. However,
little is known about how inflammatory cytokines provided to human CD8 T cells during
activation affects their susceptibility to post-activation cell death. We have examined and
compared the effects of the inflammatory cytokine IL-12, as well as the combination of IL-1,
IL-6, and IL-23 (IL-1/6/23) on the susceptibility of primary human CD8 T cells to post-
activation cell death. Human CD8 T cells activated in the presence of IL-1/6/23 underwent …