FOXP1 and PAX5 are rare but recurrent translocations partners in acute lymphoblastic leukemia

N Put, D Deeren, L Michaux, P Vandenberghe - Cancer Genetics, 2011 - Elsevier
Here, we report the case of a 57-year-old man, who was diagnosed with B-cell acute
lymphoblastic leukemia (B-ALL). His diagnostic workup identified a translocation t (3; 9)(p13;
p13). This is the fifth case reported to date that involved the forkhead box P1 gene (FOXP1)
and paired box gene 5 (PAX5). The PAX5-FOXP1 translocation is a nonrandom aberration,
which is recurrent in both childhood and in adult B-ALL, and may contribute to
leukemogenesis by blocking differentiation of hematopoietic cells into mature B-cells.