Expression of the Forkhead Transcription Factor FOXP1 is Associated with Tumor Grade and Ki67 Expression in Clear Cell Renal Cell Carcinoma

MI Toma, T Weber, M Meinhardt, S Zastrow… - Cancer …, 2011 - Taylor & Francis
MI Toma, T Weber, M Meinhardt, S Zastrow, MO Grimm, S Füssel, MP Wirth, GB Baretton
Cancer investigation, 2011Taylor & Francis
Expression of FOXP1 and Ki67 was immunohistochemically assessed on tissue microarrays
of 129 cases of clear cell renal cell carcinomas. Overall and disease-specific survival
correlated inversely with pT-category, grading and lymph node metastasis in (p<. 05).
Expression of FOXP1 correlated negatively with tumor grading (p=. 02), but neither with pT-
category nor with lymph node metastasis. Significant positive correlation was shown for Ki67
expression and tumor stage and lymph node metastasis (p<. 05). The overall survival and …
Expression of FOXP1 and Ki67 was immunohistochemically assessed on tissue microarrays of 129 cases of clear cell renal cell carcinomas. Overall and disease-specific survival correlated inversely with pT-category, grading and lymph node metastasis in (p < .05). Expression of FOXP1 correlated negatively with tumor grading (p = .02), but neither with pT-category nor with lymph node metastasis. Significant positive correlation was shown for Ki67 expression and tumor stage and lymph node metastasis (p < .05). The overall survival and the disease-specific survival correlated negatively with the Ki67 status (p < .05). FOXP1 expression negatively correlated with Ki67 expression in clear cell renal cell carcinomas (p = .036).
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