[HTML][HTML] Co-infection with Zika and dengue viruses in 2 patients, New Caledonia, 2014

M Dupont-Rouzeyrol, O O'Connor… - Emerging infectious …, 2015 - ncbi.nlm.nih.gov
M Dupont-Rouzeyrol, O O'Connor, E Calvez, M Daures, M John, JP Grangeon, AC Gourinat
Emerging infectious diseases, 2015ncbi.nlm.nih.gov
To the Editor: Dengue is the most prevalent arthropod-borne viral disease in tropical and
subtropical countries. Every year, dengue virus (DENV) infections cause more than 50
million cases, 500,000 hospitalizations, and 12,500 deaths worldwide (1). DENV belongs to
the genus Flavivirus and is transmitted by Aedes spp. mosquitoes. There are 4 distinct
serotypes (DENV-1 to DENV-4), and infection with 1 serotype does not provide long-term,
cross-protective immunity against the other 3 serotypes. In New Caledonia, DENV outbreaks …
To the Editor: Dengue is the most prevalent arthropod-borne viral disease in tropical and subtropical countries. Every year, dengue virus (DENV) infections cause more than 50 million cases, 500,000 hospitalizations, and 12,500 deaths worldwide (1). DENV belongs to the genus Flavivirus and is transmitted by Aedes spp. mosquitoes. There are 4 distinct serotypes (DENV-1 to DENV-4), and infection with 1 serotype does not provide long-term, cross-protective immunity against the other 3 serotypes. In New Caledonia, DENV outbreaks have occurred since World War II and have been caused mainly by 1 serotype/genotype introduced from a country to which dengue is hyperendemic. Since 2000, New Caledonia has had recurrent DENV-1 outbreaks (2). In 2014, circulation of DENV-1 and DENV-3 was still reported in this country (3). Zika virus (ZIKV) is an emerging mosquito-borne virus that belongs to the genus Flavivirus and was first isolated in Uganda (4). ZIKV is believed to be transmitted to humans by Aedes spp. mosquitoes. Before 2007, few human cases of infection had been reported. In 2007, the first Zika epidemic occurred in Yap, Federated States of Micronesia (5). In October 2013, a ZIKV outbreak was reported in French Polynesia (6).
In New Caledonia, the first cases of ZIKV infection imported from French Polynesia were confirmed at the end of November 2013, and the first autochthonous cases were reported by mid-January 2014. Early in February 2014, the New Caledonia Health Authority declared an outbreak situation. Since February 2014, a total of 1,385 ZIKV laboratory-confirmed cases have been detected, including 35 imported cases (32 from French Polynesia, 2 from Vanuatu,
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