[PDF][PDF] Dengue virus-induced autophagy regulates lipid metabolism

NS Heaton, G Randall - Cell host & microbe, 2010 - cell.com
Cell host & microbe, 2010cell.com
Autophagy influences numerous cellular processes, including innate and adaptive immunity
against intracellular pathogens. However, some viruses, including dengue virus (DENV),
usurp autophagy to enhance their replication. The mechanism for a positive role of
autophagy in DENV infection is unclear. We present data that DENV induction of autophagy
regulates cellular lipid metabolism. DENV infection leads to an autophagy-dependent
processing of lipid droplets and triglycerides to release free fatty acids. This results in an …
Summary
Autophagy influences numerous cellular processes, including innate and adaptive immunity against intracellular pathogens. However, some viruses, including dengue virus (DENV), usurp autophagy to enhance their replication. The mechanism for a positive role of autophagy in DENV infection is unclear. We present data that DENV induction of autophagy regulates cellular lipid metabolism. DENV infection leads to an autophagy-dependent processing of lipid droplets and triglycerides to release free fatty acids. This results in an increase in cellular β-oxidation, which generates ATP. These processes are required for efficient DENV replication. Importantly, exogenous fatty acids can supplant the requirement of autophagy in DENV replication. These results define a role for autophagy in DENV infection and provide a mechanism by which viruses can alter cellular lipid metabolism to promote their replication.
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