Immunology of bacterial polysaccharide antigens

A Weintraub - Carbohydrate research, 2003 - Elsevier
Carbohydrates in the form of capsular polysaccharides and/or lipopolysaccharides are the
major components on the surface of bacteria. These molecules are important virulence
factors in many bacteria isolated from infected persons. Immunity against these components
confers protection against the disease. However, developing vaccines based on
polysaccharides is difficult and several problems have to be solved. First of all, most of the
bacterial polysaccharides are T-lymphocyte independent antigens. Anti-polysaccharide …