Human vascular smooth muscle cells undergo vesicle-mediated calcification in response to changes in extracellular calcium and phosphate concentrations: a …
JL Reynolds, AJ Joannides, JN Skepper… - Journal of the …, 2004 - journals.lww.com
Patients with ESRD have a high circulating calcium (Ca)ื phosphate (P) product and
develop extensive vascular calcification that may contribute to their high cardiovascular
morbidity. However, the cellular mechanisms underlying vascular calcification in this context
are poorly understood. In an in vitro model, elevated Ca or P induced human vascular
smooth muscle cell (VSMC) calcification independently and synergistically, a process that
was potently inhibited by serum. Calcification was initiated by release from living VSMC of …
develop extensive vascular calcification that may contribute to their high cardiovascular
morbidity. However, the cellular mechanisms underlying vascular calcification in this context
are poorly understood. In an in vitro model, elevated Ca or P induced human vascular
smooth muscle cell (VSMC) calcification independently and synergistically, a process that
was potently inhibited by serum. Calcification was initiated by release from living VSMC of …