[HTML][HTML] Each member of the poly-r (C)-binding protein 1 (PCBP) family exhibits iron chaperone activity toward ferritin

S Leidgens, KZ Bullough, H Shi, F Li… - Journal of Biological …, 2013 - ASBMB
The mechanisms through which iron-dependent enzymes receive their metal cofactors are
largely unknown. Poly r (C)-binding protein 1 (PCBP1) is an iron chaperone for ferritin; both
PCBP1 and its paralog PCBP2 are required for iron delivery to the prolyl hydroxylase that
regulates HIF1. Here we show that PCBP2 is also an iron chaperone for ferritin. Co-
expression of PCBP2 and human ferritins in yeast activated the iron deficiency response
and increased iron deposition into ferritin. Depletion of PCBP2 in Huh7 cells diminished iron …