p53: its mutations and their impact on transcription
C Vaughan, I Pearsall, A Yeudall, SP Deb… - Mutant p53 and MDM2 in …, 2014 - Springer
C Vaughan, I Pearsall, A Yeudall, SP Deb, S Deb
Mutant p53 and MDM2 in Cancer, 2014•SpringerAbstract p53 is a tumor suppressor protein whose key function is to maintain the integrity of
the cell. Mutations in p53 have been found in up to 50% of all human cancers and cause an
increase in oncogenic phenotypes such as proliferation and tumorigenicity. Both wild-type
and mutant p53 have been shown to transactivate their target genes, either through directly
binding to DNA, or indirectly through protein-protein interactions. This review discusses
possible mechanisms behind both wild-type and mutant p53-mediated transactivation and …
the cell. Mutations in p53 have been found in up to 50% of all human cancers and cause an
increase in oncogenic phenotypes such as proliferation and tumorigenicity. Both wild-type
and mutant p53 have been shown to transactivate their target genes, either through directly
binding to DNA, or indirectly through protein-protein interactions. This review discusses
possible mechanisms behind both wild-type and mutant p53-mediated transactivation and …
Abstract
p53 is a tumor suppressor protein whose key function is to maintain the integrity of the cell. Mutations in p53 have been found in up to 50 % of all human cancers and cause an increase in oncogenic phenotypes such as proliferation and tumorigenicity. Both wild-type and mutant p53 have been shown to transactivate their target genes, either through directly binding to DNA, or indirectly through protein-protein interactions. This review discusses possible mechanisms behind both wild-type and mutant p53-mediated transactivation and touches on the concept of addiction to mutant p53 of cancer cells and how that may be used for future therapies.
Springer