Anti-tumor activity of human IgG1 anti-gp75 TA99 mAb against B16F10 melanoma in human FcgammaRI transgenic mice
P Boross, JHM Jansen, G van Tetering, M Nederend… - Immunology letters, 2014 - Elsevier
Patients suffering from advanced melanoma have a very poor prognosis. Despite recent
advances in the understanding of oncogenic mechanisms and therapeutic interventions, the
median survival of patients with metastatic disease is less than 12 months. Immunotherapy
of melanoma has been intensely investigated and holds great promises. Tyrosinase-related
protein-1 or gp75 (TYRP-1/gp75) antigen is a melanosomal polypeptide. It is the most
abundant glycoprotein synthesized by pigmented melanocytes and melanomas. It is specific …
advances in the understanding of oncogenic mechanisms and therapeutic interventions, the
median survival of patients with metastatic disease is less than 12 months. Immunotherapy
of melanoma has been intensely investigated and holds great promises. Tyrosinase-related
protein-1 or gp75 (TYRP-1/gp75) antigen is a melanosomal polypeptide. It is the most
abundant glycoprotein synthesized by pigmented melanocytes and melanomas. It is specific …