Functional diversity of helper T lymphocytes

AK Abbas, KM Murphy, A Sher - Nature, 1996 - nature.com
AK Abbas, KM Murphy, A Sher
Nature, 1996nature.com
The existence of subsets of CD4+ helper T lymphocytes that differ in their cytokine secretion
patterns and effector functions provides a framework for understanding the heterogeneity of
normal and pathological immune responses. Defining the cellular and molecular
mechanisms of helper-T-cell differentiation should lead to rational strategies for
manipulating immune responses for prophylaxis and therapy.
Abstract
The existence of subsets of CD4+ helper T lymphocytes that differ in their cytokine secretion patterns and effector functions provides a framework for understanding the heterogeneity of normal and pathological immune responses. Defining the cellular and molecular mechanisms of helper-T-cell differentiation should lead to rational strategies for manipulating immune responses for prophylaxis and therapy.
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