Switching TGFβ from a tumor suppressor to a tumor promoter

GJ Inman - Current opinion in genetics & development, 2011 - Elsevier
Current opinion in genetics & development, 2011Elsevier
TGFβ acts as a potent tumor suppressor and tumor promoter in a context dependent
manner. Tumor suppressive functions include inhibition of cell proliferation, induction of
apoptosis and regulation of autophagy. As tumors develop they switch their response to
TGFβ and utilise this factor as a potent promoter of cell motility, invasion, metastasis and
tumor stem cell maintenance. These multifactorial tumor influencing actions of TGFβ involve
regulation of an increasing number of signal transduction pathways employing a diverse …
TGFβ acts as a potent tumor suppressor and tumor promoter in a context dependent manner. Tumor suppressive functions include inhibition of cell proliferation, induction of apoptosis and regulation of autophagy. As tumors develop they switch their response to TGFβ and utilise this factor as a potent promoter of cell motility, invasion, metastasis and tumor stem cell maintenance. These multifactorial tumor influencing actions of TGFβ involve regulation of an increasing number of signal transduction pathways employing a diverse range of signaling molecules. Understanding the molecular mechanisms of how tumor cells respond to TGFβ and switch their response to this cytokine during disease progression is vital for both the development and the informed use of potentially powerful TGFβ targeted therapeutics.
Elsevier