[HTML][HTML] Iron export through the transporter ferroportin 1 is modulated by the iron chaperone PCBP2

I Yanatori, DR Richardson, K Imada, F Kishi - Journal of Biological …, 2016 - ASBMB
Ferroportin 1 (FPN1) is an iron export protein found in mammals. FPN1 is important for the
export of iron across the basolateral membrane of absorptive enterocytes and across the
plasma membrane of macrophages. The expression of FPN1 is regulated by hepcidin,
which binds to FPN1 and then induces its degradation. Previously, we demonstrated that
divalent metal transporter 1 (DMT1) interacts with the intracellular iron chaperone protein
poly (rC)-binding protein 2 (PCBP2). Subsequently, PCBP2 receives iron from DMT1 and …