Lipid transfer and metabolism across the endolysosomal–mitochondrial boundary

T Daniele, MV Schiaffino - Biochimica et Biophysica Acta (BBA)-Molecular …, 2016 - Elsevier
T Daniele, MV Schiaffino
Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids, 2016Elsevier
Lysosomes and mitochondria occupy a central stage in the maintenance of cellular
homeostasis, by playing complementary roles in nutrient sensing and energy metabolism.
Specifically, these organelles function as signaling hubs that integrate environmental and
endogenous stimuli with specific metabolic responses. In particular, they control various lipid
biosynthetic and degradative pipelines, either directly or indirectly, by regulating major
cellular metabolic pathways, and by physical and functional connections established with …
Abstract
Lysosomes and mitochondria occupy a central stage in the maintenance of cellular homeostasis, by playing complementary roles in nutrient sensing and energy metabolism. Specifically, these organelles function as signaling hubs that integrate environmental and endogenous stimuli with specific metabolic responses. In particular, they control various lipid biosynthetic and degradative pipelines, either directly or indirectly, by regulating major cellular metabolic pathways, and by physical and functional connections established with each other and with other organelles. Membrane contact sites allow the exchange of ions and molecules between organelles, even without membrane fusion, and are privileged routes for lipid transfer among different membrane compartments. These inter-organellar connections typically involve the endoplasmic reticulum. Direct membrane contacts have now been described also between lysosomes, autophagosomes, lipid droplets, and mitochondria. This review focuses on these recently identified membrane contact sites, and on their role in lipid biosynthesis, exchange, turnover and catabolism. This article is part of a Special Issue entitled: The cellular lipid landscape edited by Tim P. Levine and Anant K. Menon.
Elsevier