[HTML][HTML] Mirk protein kinase is activated by MKK3 and functions as a transcriptional activator of HNF1α
S Lim, K Jin, E Friedman - Journal of Biological Chemistry, 2002 - ASBMB
Mirk/Dyrk1B is an arginine-directed serine/threonine protein kinase that is expressed at low
levels in most normal tissues but at elevated levels in many tumor cell lines and in normal
skeletal muscle. Colon carcinoma cell lines stably overexpressing Mirk proliferated in serum-
free medium, but the mechanism of Mirk action is unknown. DCoHm (dimerization cofactor of
hepatocyte nuclear factor 1α (HNF1α) from muscle), a novel gene of the DCoH family with
78% amino acid identity to DCoH, was identified as a Mirk-binding protein by yeast two …
levels in most normal tissues but at elevated levels in many tumor cell lines and in normal
skeletal muscle. Colon carcinoma cell lines stably overexpressing Mirk proliferated in serum-
free medium, but the mechanism of Mirk action is unknown. DCoHm (dimerization cofactor of
hepatocyte nuclear factor 1α (HNF1α) from muscle), a novel gene of the DCoH family with
78% amino acid identity to DCoH, was identified as a Mirk-binding protein by yeast two …