[HTML][HTML] The histone deacetylase 9 gene encodes multiple protein isoforms
Histone deacetylases (HDACs) perform an important function in transcriptional regulation by
modifying the core histones of the nucleosome. We have now fully characterized a new
member of the Class II HDAC family, HDAC9. The enzyme contains a conserved
deacetylase domain, represses reporter activity when recruited to a promoter, and utilizes
histones H3 and H4 as substrates in vitro and in vivo. HDAC9 is expressed in a tissue-
specific pattern that partially overlaps that of HDAC4. Within the human hematopoietic …
modifying the core histones of the nucleosome. We have now fully characterized a new
member of the Class II HDAC family, HDAC9. The enzyme contains a conserved
deacetylase domain, represses reporter activity when recruited to a promoter, and utilizes
histones H3 and H4 as substrates in vitro and in vivo. HDAC9 is expressed in a tissue-
specific pattern that partially overlaps that of HDAC4. Within the human hematopoietic …