[HTML][HTML] A growth-suppressive function for the c-fes protein-tyrosine kinase in colorectal cancer

FJ Delfino, H Stevenson, TE Smithgall - Journal of biological chemistry, 2006 - ASBMB
The human c-fes locus encodes a non-receptor protein-tyrosine kinase implicated in
myeloid, vascular endothelial, and neuronal cell differentiation. A recent analysis of the
tyrosine kinome in colorectal cancer identified c-fes as one of only seven genes with
consistent kinase domain mutations. Although four mutations were identified (M704V,
R706Q, V743M, S759F), the consequences of these mutations on Fes kinase activity were
not explored. To address this issue, Fes mutants with these substitutions were co-expressed …