Mismatch repair (MMR) proteins have critical roles in the maintenance of genomic stability,
both class-switch recombination and somatic hypermutation of immunoglobulin genes and
disease-associated trinucleotide repeat expansions. In the genetic absence of MMR, certain
tissues are predisposed to mutations and cancer. MMR proteins are involved in various
functions including protection from replication-associated and non-mitotic mutations, as well
as driving programmed and deleterious mutations, including disease-causing trinucleotide …