Expression of muscle segment homeobox genes in the developing myocardium

CJJ Boogerd, AFM Moorman… - The Anatomical Record …, 2010 - Wiley Online Library
The Anatomical Record: Advances in Integrative Anatomy and …, 2010Wiley Online Library
Msx1 and Msx2 are essential for the development of many organs. In the heart, they act
redundantly in development of the cardiac cushions. Additionally, Msx2 is expressed in the
developing conduction system. However, the exact expression of Msx1 has not been
established. We show that Msx1 is expressed in the cardiac cushions, but not in the
myocardium. In Msx2‐null mice, Msx1 is not ectopically expressed in the myocardium. The
absence of myocardial defects in the Msx2 knock‐out can therefore not be attributed to a …
Abstract
Msx1 and Msx2 are essential for the development of many organs. In the heart, they act redundantly in development of the cardiac cushions. Additionally, Msx2 is expressed in the developing conduction system. However, the exact expression of Msx1 has not been established. We show that Msx1 is expressed in the cardiac cushions, but not in the myocardium. In Msx2‐null mice, Msx1 is not ectopically expressed in the myocardium. The absence of myocardial defects in the Msx2 knock‐out can therefore not be attributed to a redundant action of Msx1 in the myocardium. Anat Rec, 2010. © 2010 Wiley‐Liss, Inc.
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