The pathogenesis of atrial and atrioventricular septal defects with special emphasis on the role of the dorsal mesenchymal protrusion
LE Briggs, J Kakarla, A Wessels - Differentiation, 2012 - Elsevier
Partitioning of the four-chambered heart requires the proper formation, interaction and fusion
of several mesenchymal tissues derived from different precursor populations that together
form the atrioventricular mesenchymal complex. This includes the major endocardial
cushions and the mesenchymal cap of the septum primum, which are of endocardial origin,
and the dorsal mesenchymal protrusion (DMP), which is derived from the Second Heart
Field. Failure of these structures to develop and/or fully mature results in atrial septal defects …
of several mesenchymal tissues derived from different precursor populations that together
form the atrioventricular mesenchymal complex. This includes the major endocardial
cushions and the mesenchymal cap of the septum primum, which are of endocardial origin,
and the dorsal mesenchymal protrusion (DMP), which is derived from the Second Heart
Field. Failure of these structures to develop and/or fully mature results in atrial septal defects …