[HTML][HTML] Signals emanating from the membrane proximal region of the thrombopoietin receptor (mpl) support hematopoietic stem cell self-renewal
W Tong, YM Ibarra, HF Lodish - Experimental hematology, 2007 - Elsevier
OBJECTIVE: Studies using thrombopoietin−/−(TPO−/−) or TPO receptor, mpl−/− mice have
established a critical role for TPO/mpl signaling in hematopoietic stem cell (HSC)
development. In this study, we further dissected mpl signaling in both megakaryopoiesis and
HSC function, using mice bearing a truncated mpl receptor lacking the distal 60 amino acids
(Δ60). This deletion removes three major signaling tyrosines on the mpl cytoplasmic domain,
but retains the membrane proximal Box1 and Box2 domains required for JAK2 activation …
established a critical role for TPO/mpl signaling in hematopoietic stem cell (HSC)
development. In this study, we further dissected mpl signaling in both megakaryopoiesis and
HSC function, using mice bearing a truncated mpl receptor lacking the distal 60 amino acids
(Δ60). This deletion removes three major signaling tyrosines on the mpl cytoplasmic domain,
but retains the membrane proximal Box1 and Box2 domains required for JAK2 activation …