TLR7, IFNγ, and T-bet: their roles in the development of ABCs in female-biased autoimmunity
K Rubtsova, P Marrack, AV Rubtsov - Cellular immunology, 2015 - Elsevier
The majority of autoimmune diseases have a strong gender bias, affecting mostly females.
Gender-specific factors like sex-hormones, the presence or absence of a second X
chromosome, and gender-specific gut microbiota may contribute to this bias. In this review
we will discuss the role of the X chromosome encoded toll-like receptor 7 (TLR7) and
interferon gamma (IFNγ) in the development of autoimmunity. We will also review recent
data indicating how these factors may affect an immune response in a gender-dependent …
Gender-specific factors like sex-hormones, the presence or absence of a second X
chromosome, and gender-specific gut microbiota may contribute to this bias. In this review
we will discuss the role of the X chromosome encoded toll-like receptor 7 (TLR7) and
interferon gamma (IFNγ) in the development of autoimmunity. We will also review recent
data indicating how these factors may affect an immune response in a gender-dependent …