[HTML][HTML] Islet oxygen consumption and insulin secretion tightly coupled to calcium derived from L-type calcium channels but not from the endoplasmic reticulum
The aim of the study was to test whether the source of intracellular calcium (Ca 2+) is a
determinant of beta cell function. We hypothesized that elevations in cytosolic Ca 2+ caused
by the release of Ca 2+ from the endoplasmic reticulum (ER) have little physiologic impact
on oxygen consumption and insulin secretion. Ca 2+ release from the ER was induced in
isolated rat islets by acetylcholine and response of oxygen consumption rate (OCR), NAD
(P) H, cytosolic Ca 2+, and insulin secretory rate (ISR) were measured. Glucose increased …
determinant of beta cell function. We hypothesized that elevations in cytosolic Ca 2+ caused
by the release of Ca 2+ from the endoplasmic reticulum (ER) have little physiologic impact
on oxygen consumption and insulin secretion. Ca 2+ release from the ER was induced in
isolated rat islets by acetylcholine and response of oxygen consumption rate (OCR), NAD
(P) H, cytosolic Ca 2+, and insulin secretory rate (ISR) were measured. Glucose increased …