[HTML][HTML] IL-6 exhibits both cis-and trans-signaling in osteocytes and osteoblasts, but only trans-signaling promotes bone formation and osteoclastogenesis
NE McGregor, M Murat, J Elango, IJ Poulton… - Journal of Biological …, 2019 - ASBMB
Interleukin 6 (IL-6) supports development of bone-resorbing osteoclasts by acting early in
the osteoblast lineage via membrane-bound (cis) or soluble (trans) receptors. Here, we
investigated how IL-6 signals and modifies gene expression in differentiated osteoblasts
and osteocytes and determined whether these activities can promote bone formation or
support osteoclastogenesis. Moreover, we used a genetically altered mouse with circulating
levels of the pharmacological IL-6 trans-signaling inhibitor sgp130-Fc to determine whether …
the osteoblast lineage via membrane-bound (cis) or soluble (trans) receptors. Here, we
investigated how IL-6 signals and modifies gene expression in differentiated osteoblasts
and osteocytes and determined whether these activities can promote bone formation or
support osteoclastogenesis. Moreover, we used a genetically altered mouse with circulating
levels of the pharmacological IL-6 trans-signaling inhibitor sgp130-Fc to determine whether …