Tetracyclines are broad-spectrum antibiotics that act as such at the ribosomal level where
they interfere with protein synthesis. They were first widely prescribed by dermatologists in
the early 1950s when it was discovered that they were effective as a treatment for acne.
More recently, biologic actions affecting inflammation, proteolysis, angiogenesis, apoptosis,
metal chelation, ionophoresis, and bone metabolism have been researched. The
therapeutic effects of tetracycline and its analogues in various diseases have also been …