Expansion of circulating follicular T helper cells associates with disease severity in childhood atopic dermatitis
Abstract Follicular helper T (T FH) cells play crucial role in B-cell differentiation and antibody
production. Although, atopic dermatitis (AD) is often associated with increased serum IgE
levels, B-cell mediated responses have not been studied thoroughly. The aim of our study
was to investigate the proportion of T FH-like cells in the disease. Twelve children and 17
adults with AD as well as 14 healthy controls were enrolled in the study. The frequency of
CD4+ CXCR5+ ICOS+ PD-1+ T FH-like cells and their IL-21 cytokine production were …
production. Although, atopic dermatitis (AD) is often associated with increased serum IgE
levels, B-cell mediated responses have not been studied thoroughly. The aim of our study
was to investigate the proportion of T FH-like cells in the disease. Twelve children and 17
adults with AD as well as 14 healthy controls were enrolled in the study. The frequency of
CD4+ CXCR5+ ICOS+ PD-1+ T FH-like cells and their IL-21 cytokine production were …
