[HTML][HTML] Interleukin (IL) 1β induction of IL-6 is mediated by a novel phosphatidylinositol 3-kinase-dependent AKT/IκB kinase α pathway targeting activator protein-1
CM Cahill, JT Rogers - Journal of Biological Chemistry, 2008 - ASBMB
Here we describe a novel role for the phosphatidylinositol 3-kinase/AKT pathway in
mediating induction of interleukin-6 (IL-6) in response to IL-1. Pharmacological inhibition of
phosphatidylinositol 3-kinase (PI3K) inhibited IL-6 mRNA and protein production.
Overexpression of either dominant-negative AKT or IκB kinase α mutant, IKKαT23A,
containing a mutation in a functional AKT phosphorylation site, shown previously to be
important for NFκB activation, completely abrogated IL-6 promoter activation in response to …
mediating induction of interleukin-6 (IL-6) in response to IL-1. Pharmacological inhibition of
phosphatidylinositol 3-kinase (PI3K) inhibited IL-6 mRNA and protein production.
Overexpression of either dominant-negative AKT or IκB kinase α mutant, IKKαT23A,
containing a mutation in a functional AKT phosphorylation site, shown previously to be
important for NFκB activation, completely abrogated IL-6 promoter activation in response to …
