Degradation of endoplasmic reticulum (ER) quality control substrates requires transport between the ER and Golgi
SR Caldwell, KJ Hill, AA Cooper - Journal of Biological Chemistry, 2001 - ASBMB
Endoplasmic reticulum (ER) quality control (ERQC) components retain and degrade
misfolded proteins, and our results have found that the degradation of the soluble ERQC
substrates CPY* and PrA* but not membrane spanning ERQC substrates requires transport
between the ER and Golgi. Stabilization of these misfolded soluble proteins was seen in
cells lacking Erv29p, a probable Golgi localized protein that cycles through the ER by means
of a di-lysine ER retrieval motif (KKKIY). Cells lacking Erv29p also displayed severely …
misfolded proteins, and our results have found that the degradation of the soluble ERQC
substrates CPY* and PrA* but not membrane spanning ERQC substrates requires transport
between the ER and Golgi. Stabilization of these misfolded soluble proteins was seen in
cells lacking Erv29p, a probable Golgi localized protein that cycles through the ER by means
of a di-lysine ER retrieval motif (KKKIY). Cells lacking Erv29p also displayed severely …
