Expression of cystic fibrosis transmembrane conductance regulator in the human distal lung
A Regnier, L Dannhoffer, S Blouquit-Laye, M Bakari… - Human pathology, 2008 - Elsevier
The determination of the expression of cystic fibrosis transmembrane conductance regulator
(CFTR) in the lung is essential for a full understanding of the normal lung physiology and the
pathogenesis of the lung disease in cystic fibrosis (CF). However, studies on the expression
of CFTR in the distal adult human lung have yielded conflicting results despite functional
evidence of expression of CFTR in bronchiolar and alveolar epithelial cells. We used 2 high-
affinity monoclonal anti-CFTR antibodies, MAb24-1 and MAb13-1, to determine the …
(CFTR) in the lung is essential for a full understanding of the normal lung physiology and the
pathogenesis of the lung disease in cystic fibrosis (CF). However, studies on the expression
of CFTR in the distal adult human lung have yielded conflicting results despite functional
evidence of expression of CFTR in bronchiolar and alveolar epithelial cells. We used 2 high-
affinity monoclonal anti-CFTR antibodies, MAb24-1 and MAb13-1, to determine the …