Mechanisms of DNA methylation and demethylation in mammals

G Auclair, M Weber - Biochimie, 2012 - Elsevier
Cytosine methylation is an epigenetically propagated DNA modification that can modify how
the DNA molecule is recognized and expressed. DNA methylation undergoes extensive
reprogramming during mammalian embryogenesis and is directly linked to the regulation of
pluripotency and cellular identity. Studying its regulation is also important for a better
understanding of the many diseases that show epigenetic deregulations, in particular,
cancer. In the recent years, a lot of progress has been made to characterize the profiles of …