Choline deficiency: a cause of hepatic steatosis during parenteral nutrition that can be reversed with intravenous choline supplementation
AL Buchman, MD Dubin, AA Moukarzel, DJ Jenden… - Hepatology, 1995 - journals.lww.com
Patients receiving long-term total parenteral nutrition (TPN) develop hepatic steatosis as a
complication. Our previous studies have shown this to be caused, at least in part, by choline
deficiency. We studied four patients (1 man, 3 women) aged 50±13 years who had low
plasma-free choline concentrations 4.8±1.7 (normal, 11.4±3.7 nmol/mL). The patients had
received TPN for 9.7±4.7 years. They received parenteral nutrition solutions containing
choline chloride (1 to 4 g/d) for 6 weeks. Abdominal computed tomography (CT) was …
complication. Our previous studies have shown this to be caused, at least in part, by choline
deficiency. We studied four patients (1 man, 3 women) aged 50±13 years who had low
plasma-free choline concentrations 4.8±1.7 (normal, 11.4±3.7 nmol/mL). The patients had
received TPN for 9.7±4.7 years. They received parenteral nutrition solutions containing
choline chloride (1 to 4 g/d) for 6 weeks. Abdominal computed tomography (CT) was …