Palmitate activates mTOR/p70S6K through AMPK inhibition and hypophosphorylation of raptor in skeletal muscle cells: Reversal by oleate is similar to metformin
B Kwon, HW Querfurth - Biochimie, 2015 - Elsevier
Excessive saturated free fatty acids (SFFAs; eg palmitate) in blood are a pathogenic factor in
diabetes, obesity, cardiovascular disease and liver failure. In contrast, monounsaturated free
fatty acids (eg oleate) prevent the toxic effect of SFFAs in various types of cells. The
mechanism is poorly understood and involvement of the mTOR complex is untested. In the
present study, we demonstrate that oleate preconditioning, as well as coincubation,
completely prevented palmitate-induced markers of inflammatory signaling, insulin …
diabetes, obesity, cardiovascular disease and liver failure. In contrast, monounsaturated free
fatty acids (eg oleate) prevent the toxic effect of SFFAs in various types of cells. The
mechanism is poorly understood and involvement of the mTOR complex is untested. In the
present study, we demonstrate that oleate preconditioning, as well as coincubation,
completely prevented palmitate-induced markers of inflammatory signaling, insulin …