Comparison of domain structures of ADAMTSs, ADAMs and SVMPs. The first three boxes of each bar represent, respectively, the common prodomain and the metalloprotease and disintegrin domains present in all of the members of adamalysin family. ADAMTSs also possess a thrombospondin domain but lack the cysteine-rich, EGF-like, transmembrane, and cytoplasmic domains found in ADAMs. SVMPs and ADAMTSs do not contain transmembrane domains and are therefore secreted, whereas ADAMs are transmembrane proteins that localize to the cell surface.