The role of PI 3-kinase in insulin action
DR Alessi, CP Downes - Biochimica et Biophysica Acta (BBA)-Molecular …, 1998 - Elsevier
This review focuses on the recent advances made in our understanding of the mechanism
by which insulin induces the activation of PI 3-kinase (s) whose role is to generate 3-
phosphoinositide lipids which are the second messenger of the insulin signalling pathway.
The mechanism by which these signalling molecules induce the activation of downstream
signalling pathways leading to the activation of protein kinase B (PKB, also known as Akt)
and other kinases is also discussed. PKB is likely to be a major mediator of many of the …
by which insulin induces the activation of PI 3-kinase (s) whose role is to generate 3-
phosphoinositide lipids which are the second messenger of the insulin signalling pathway.
The mechanism by which these signalling molecules induce the activation of downstream
signalling pathways leading to the activation of protein kinase B (PKB, also known as Akt)
and other kinases is also discussed. PKB is likely to be a major mediator of many of the …
