[HTML][HTML] Reactive oxygen species mediate the activation of Akt/protein kinase B by angiotensin II in vascular smooth muscle cells
M Ushio-Fukai, RW Alexander, M Akers, QQ Yin… - Journal of Biological …, 1999 - ASBMB
Angiotensin II, a hypertrophic/anti-apoptotic hormone, utilizes reactive oxygen species
(ROS) as growth-related signaling molecules in vascular smooth muscle cells (VSMCs).
Recently, the cell survival protein kinase Akt/protein kinase B (PKB) was proposed to be
involved in protein synthesis. Here we show that angiotensin II causes rapid
phosphorylation of Akt/PKB (6-±0.4-fold increase). Exogenous H 2 O 2 (50–200 μm) also
stimulates Akt/PKB phosphorylation (maximal 8-±0.2-fold increase), suggesting that Akt/PKB …
(ROS) as growth-related signaling molecules in vascular smooth muscle cells (VSMCs).
Recently, the cell survival protein kinase Akt/protein kinase B (PKB) was proposed to be
involved in protein synthesis. Here we show that angiotensin II causes rapid
phosphorylation of Akt/PKB (6-±0.4-fold increase). Exogenous H 2 O 2 (50–200 μm) also
stimulates Akt/PKB phosphorylation (maximal 8-±0.2-fold increase), suggesting that Akt/PKB …
