Protective genes expressed in endothelial cells: a regulatory response to injury
FH Bach, WW Hancock, C Ferran - Immunology today, 1997 - cell.com
FH Bach, WW Hancock, C Ferran
Immunology today, 1997•cell.comEndothelial cells (ECs) have evolved to guard against insults that incite inflammation.
Response to injury is an active process that, if uncontrolled, can progress to EC death
(apoptosis). Here Fritz bach and colleagues suggest that ECs have a balancing component
to their proinflammatory response: they upregulate a set of protective genes, including anti-
apoptetic genes, that serve to limit the activation process and thereby regulate the response
to injury.
Response to injury is an active process that, if uncontrolled, can progress to EC death
(apoptosis). Here Fritz bach and colleagues suggest that ECs have a balancing component
to their proinflammatory response: they upregulate a set of protective genes, including anti-
apoptetic genes, that serve to limit the activation process and thereby regulate the response
to injury.
Abstract
Endothelial cells (ECs) have evolved to guard against insults that incite inflammation. Response to injury is an active process that, if uncontrolled, can progress to EC death (apoptosis). Here Fritz bach and colleagues suggest that ECs have a balancing component to their proinflammatory response: they upregulate a set of protective genes, including anti-apoptetic genes, that serve to limit the activation process and thereby regulate the response to injury.
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