[HTML][HTML] Oxidation of Bromide by the Human Leukocyte Enzymes Myeloperoxidase and Eosinophil Peroxidase: FORMATION OF BROMAMINES (∗)
EL Thomas, PM Bozeman, MM Jefferson… - Journal of Biological …, 1995 - ASBMB
Myeloperoxidase and eosinophil peroxidase catalyzed the oxidation of bromide ion by
hydrogen peroxide (H 2 O 2) and produced a brominating agent that reacted with amine
compounds to form bromamines, which are long-lived oxidants containing covalent nitrogen-
bromine bonds. Results were consistent with oxidation of bromide to an equilibrium mixture
of hypobromous acid (HOBr) and hypobromite ion (OBr-). Up to 1 mol of bromamine was
produced per mole of H 2 O 2, indicating that bromamine formation prevented the reduction …
hydrogen peroxide (H 2 O 2) and produced a brominating agent that reacted with amine
compounds to form bromamines, which are long-lived oxidants containing covalent nitrogen-
bromine bonds. Results were consistent with oxidation of bromide to an equilibrium mixture
of hypobromous acid (HOBr) and hypobromite ion (OBr-). Up to 1 mol of bromamine was
produced per mole of H 2 O 2, indicating that bromamine formation prevented the reduction …