[HTML][HTML] Cardiac specific overexpression of transglutaminase II (Gh) results in a unique hypertrophy phenotype independent of phospholipase C activation
K Small, JF Feng, J Lorenz, ET Donnelly, A Yu… - Journal of Biological …, 1999 - ASBMB
Tissue type transglutaminase (TGII, also known as G h) has been considered a
multifunctional protein, with both transglutaminase and GTPase activity. The role of the latter
function, which is proposed as a coupling mechanism between α 1-adrenergic receptors
and phospholipase C (PLC), is not well defined. TGII was overexpressed in transgenic mice
in a cardiac specific manner to delineated relevant signaling pathways and their
consequences in the heart. Cardiac transglutaminase activity in the highest expressing line …
multifunctional protein, with both transglutaminase and GTPase activity. The role of the latter
function, which is proposed as a coupling mechanism between α 1-adrenergic receptors
and phospholipase C (PLC), is not well defined. TGII was overexpressed in transgenic mice
in a cardiac specific manner to delineated relevant signaling pathways and their
consequences in the heart. Cardiac transglutaminase activity in the highest expressing line …