[HTML][HTML] Defective β-adrenergic receptor signaling precedes the development of dilated cardiomyopathy in transgenic mice with calsequestrin overexpression
MC Cho, A Rapacciuolo, WJ Koch, Y Kobayashi… - Journal of Biological …, 1999 - ASBMB
Calsequestrin is a high capacity Ca 2+-binding protein in the junctional sarcoplasmic
reticulum that forms a quaternary complex with junctin, triadin, and the ryanodine receptor.
Transgenic mice with cardiac-targeted calsequestrin overexpression show marked
suppression of Ca 2+-induced Ca 2+ release, myocyte hypertrophy, and premature death by
16 weeks of age (Jones, LR, Suzuki, YJ, Wang, W., Kobayashi, YM, Ramesh, V., Franzini-
Armstrong, C., Cleemann, L., and Morad, M.(1998) J. Clin. Invest. 101, 1385–1393). To …
reticulum that forms a quaternary complex with junctin, triadin, and the ryanodine receptor.
Transgenic mice with cardiac-targeted calsequestrin overexpression show marked
suppression of Ca 2+-induced Ca 2+ release, myocyte hypertrophy, and premature death by
16 weeks of age (Jones, LR, Suzuki, YJ, Wang, W., Kobayashi, YM, Ramesh, V., Franzini-
Armstrong, C., Cleemann, L., and Morad, M.(1998) J. Clin. Invest. 101, 1385–1393). To …