Demonstration of the release of an epithelium-derived inhibitory factor from a novel preparation of guinea-pig trachea
DWP Hay, RM Muccitelli, DL Horstemeyer… - European journal of …, 1987 - Elsevier
DWP Hay, RM Muccitelli, DL Horstemeyer, KA Wilson, D Raeburn
European journal of pharmacology, 1987•ElsevierUsing a novel preparation of guinea-pig trachea, direct evidence was obtained for the
release of an epithelium-derived inhibitory factor modulating contractions elicited by antigen.
Thus, epithelium removal produced a 6.1-fold leftward shift in ovalbumin concentration-
response curves in tracheal strips from ovalbumin-sensitized guinea-pigs. This increase in
sensitivity to ovalbumin was not evident when a tracheal portion containing epithelium was
positioned in close proximity to the tissue from which tension was recorded.
release of an epithelium-derived inhibitory factor modulating contractions elicited by antigen.
Thus, epithelium removal produced a 6.1-fold leftward shift in ovalbumin concentration-
response curves in tracheal strips from ovalbumin-sensitized guinea-pigs. This increase in
sensitivity to ovalbumin was not evident when a tracheal portion containing epithelium was
positioned in close proximity to the tissue from which tension was recorded.
Abstract
Using a novel preparation of guinea-pig trachea, direct evidence was obtained for the release of an epithelium-derived inhibitory factor modulating contractions elicited by antigen. Thus, epithelium removal produced a 6.1-fold leftward shift in ovalbumin concentration-response curves in tracheal strips from ovalbumin-sensitized guinea-pigs. This increase in sensitivity to ovalbumin was not evident when a tracheal portion containing epithelium was positioned in close proximity to the tissue from which tension was recorded.
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