Novel human immunodeficiencies reveal the essential role of type-1 cytokines in immunity to intracellular bacteria
THM Ottenhoff, D Kumararatne, JL Casanova - Immunology today, 1998 - cell.com
THM Ottenhoff, D Kumararatne, JL Casanova
Immunology today, 1998•cell.comStudies of patients with severe infections arising from poorly pathogenic mycobacterium or
Salmonella species have revealed genetic mutations in type-1 cytokine (IL-12p40) or type-1
cytokine receptor (IFN-γR1, IFN-γR2, IL-12Rβ1) genes. This article summarizes the findings
and discusses their implications.
Salmonella species have revealed genetic mutations in type-1 cytokine (IL-12p40) or type-1
cytokine receptor (IFN-γR1, IFN-γR2, IL-12Rβ1) genes. This article summarizes the findings
and discusses their implications.
Abstract
Studies of patients with severe infections arising from poorly pathogenic mycobacterium or Salmonella species have revealed genetic mutations in type-1 cytokine (IL-12p40) or type-1 cytokine receptor (IFN-γR1, IFN-γR2, IL-12Rβ1) genes. This article summarizes the findings and discusses their implications.
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