Matrix metalloproteinase degradation of extracellular matrix: biological consequences

SD Shapiro - Current opinion in cell biology, 1998 - Elsevier
Current opinion in cell biology, 1998Elsevier
Targeted mutagenesis has allowed investigators to perform controlled experiments in
mammals and determine the contribution of individual proteins to physiologic and pathologic
processes. Recent lessons learned from matrix metalloproteinase gene targeted mice and
other in vivo observations have given new life to old concepts regarding the role of
proteolytic fragments of extracellular matrix proteins in regulating a variety of critical
processes in cell biology.
Targeted mutagenesis has allowed investigators to perform controlled experiments in mammals and determine the contribution of individual proteins to physiologic and pathologic processes. Recent lessons learned from matrix metalloproteinase gene targeted mice and other in vivo observations have given new life to old concepts regarding the role of proteolytic fragments of extracellular matrix proteins in regulating a variety of critical processes in cell biology.
Elsevier