[HTML][HTML] Fibronectin-mediated cell adhesion is required for induction of 92-kDa type IV collagenase/gelatinase (MMP-9) gene expression during macrophage …

B Xie, A Laouar, E Huberman - Journal of Biological Chemistry, 1998 - ASBMB
Induction of the 92-kDa gelatinase (MMP-9) gene expression is associated with
macrophage differentiation. In this study, we explored the regulatory mechanisms underlying
this differentiation-associated MMP-9 gene expression in human HL-60 myeloid leukemia
cells and human peripheral blood monocytes. Phorbol 12-myristate 13-acetate (PMA)
markedly inducedMMP-9 gene expression in HL-60 cells; the induction closely paralleled
the timing and extent of PMA-induced cell adhesion and spreading, a hallmark of …