[HTML][HTML] Phosphorylation and cell cycle-dependent regulation of Na+/H+ exchanger regulatory factor-1 by Cdc2 kinase
J He, AG Lau, MB Yaffe, RA Hall - Journal of Biological Chemistry, 2001 - ASBMB
Na+/H+ exchanger regulatory factor (NHERF)-1 is a PDZ domain-containing adaptor protein
known to bind to various receptors, channels, cytoskeletal elements, and cytoplasmic
signaling proteins. We report here that the phosphorylation state of NHERF-1 is profoundly
regulated by the cell cycle: NHERF-1 in HeLa cells is hyperphosphorylated in mitosis phase
and much less phosphorylated at other points of the cell cycle. This mitosis phase-
dependent phosphorylation of NHERF-1 could be blocked by roscovitine, consistent with …
known to bind to various receptors, channels, cytoskeletal elements, and cytoplasmic
signaling proteins. We report here that the phosphorylation state of NHERF-1 is profoundly
regulated by the cell cycle: NHERF-1 in HeLa cells is hyperphosphorylated in mitosis phase
and much less phosphorylated at other points of the cell cycle. This mitosis phase-
dependent phosphorylation of NHERF-1 could be blocked by roscovitine, consistent with …