β-Amyloid peptide (Aβ), which plays a central role in the pathogenesis of Alzheimer's
disease, is derived from the transmembrane β-amyloid precursor protein (APP) by
proteolytic processing. Although mechanisms associated with Aβ generation are not fully
understood, it is known that Aβ can be generated within endosomal compartments upon
internalization of APP from the cell surface. The low density lipoprotein receptor-related
protein (LRP) was previously shown to mediate the endocytosis of APP isoforms containing …