The cloned locus of enterocyte effacement from enterohemorrhagic Escherichia coli O157: H7 is unable to confer the attaching and effacing phenotype upon E. coli K …
SJ Elliott, J Yu, JB Kaper - Infection and immunity, 1999 - Am Soc Microbiol
SJ Elliott, J Yu, JB Kaper
Infection and immunity, 1999•Am Soc MicrobiolThe locus of enterocyte effacement (LEE) pathogenicity island of enterohemorrhagic
Escherichia coli (EHEC) O157: H7 possesses the same genes in identical order and
orientation as the LEE of enteropathogenic E. coli (EPEC) O127: H6 but is unable to form
attaching and effacing (A/E) lesions or to secrete Esp proteins when it is cloned in an E. coli
K-12 background. The A/E phenotype could not be restored by trans complementation with a
variety of cloned EPEC LEE fragments, suggesting functional and/or regulatory differences …
Escherichia coli (EHEC) O157: H7 possesses the same genes in identical order and
orientation as the LEE of enteropathogenic E. coli (EPEC) O127: H6 but is unable to form
attaching and effacing (A/E) lesions or to secrete Esp proteins when it is cloned in an E. coli
K-12 background. The A/E phenotype could not be restored by trans complementation with a
variety of cloned EPEC LEE fragments, suggesting functional and/or regulatory differences …
Abstract
The locus of enterocyte effacement (LEE) pathogenicity island of enterohemorrhagic Escherichia coli (EHEC) O157:H7 possesses the same genes in identical order and orientation as the LEE of enteropathogenic E. coli (EPEC) O127:H6 but is unable to form attaching and effacing (A/E) lesions or to secrete Esp proteins when it is cloned in an E. coli K-12 background. The A/E phenotype could not be restored by trans complementation with a variety of cloned EPEC LEE fragments, suggesting functional and/or regulatory differences between the LEE pathogenicity islands of EPEC O127:H6 and EHEC O157:H7.
American Society for Microbiology