Structure-function analysis of CD14 as a soluble receptor for lipopolysaccharide
S Viriyakosol, JC Mathison, PS Tobias… - Journal of Biological …, 2000 - ASBMB
CD14 is a glycophosphatidylinositol-linked protein expressed by myeloid cells and also
circulates as a plasma protein lacking the glycophosphatidylinositol anchor. Both membrane
and soluble CD14 function to enhance activation of cells by lipopolysaccharide (LPS), which
we refer to as receptor function. We have previously reported the LPS binding and cell
activation functions of a group of five deletion mutants of CD14 (Viriyakosol, S., and Kirkland,
TN (1995) J. Biol. Chem. 270, 361–368). We have now studied the functional impact of these …
circulates as a plasma protein lacking the glycophosphatidylinositol anchor. Both membrane
and soluble CD14 function to enhance activation of cells by lipopolysaccharide (LPS), which
we refer to as receptor function. We have previously reported the LPS binding and cell
activation functions of a group of five deletion mutants of CD14 (Viriyakosol, S., and Kirkland,
TN (1995) J. Biol. Chem. 270, 361–368). We have now studied the functional impact of these …
