[HTML][HTML] Sterol-dependent transcriptional regulation of sterol regulatory element-binding protein-2
R Sato, J Inoue, Y Kawabe, T Kodama, T Takano… - Journal of Biological …, 1996 - ASBMB
We show in this manuscript that expression of the mRNA for sterol regulatory element-
binding protein-2 (SREBP-2) is regulated by the cellular sterol level in cultured HeLa cells.
We have cloned the 5′-flanking region of the gene encoding human SREBP-2.
Characterization of this region shows the minimum 50-base pair segment, which contains a
10-base pair sterol regulatory element 1 (SRE-1) identical to the one in the human LDL
receptor promoter, confers sterol responsiveness when fused to the luciferase reporter gene …
binding protein-2 (SREBP-2) is regulated by the cellular sterol level in cultured HeLa cells.
We have cloned the 5′-flanking region of the gene encoding human SREBP-2.
Characterization of this region shows the minimum 50-base pair segment, which contains a
10-base pair sterol regulatory element 1 (SRE-1) identical to the one in the human LDL
receptor promoter, confers sterol responsiveness when fused to the luciferase reporter gene …