Virulence and Immunogenicity in Experimental Animals of Bacillus anthracis Strains Harbouring or Lacking 110 MDa and 60 MDa Plasmids
I Uchida, K Hashimoto, N Terakado - Microbiology, 1986 - microbiologyresearch.org
I Uchida, K Hashimoto, N Terakado
Microbiology, 1986•microbiologyresearch.orgA comparative study was made of the virulence and immunogenicity in mice or guinea pigs
of Bacillus anthracis strains harbouring 110 MDa and/or 60 MDa plasmids. Strains cured of
the 110 MDa or the 60 MDa plasmid were more than 100-fold less virulent to mice than were
the parental strains harbouring these plasmids. Guinea-pigs immunized with plasmid-free
derivatives of the non-encapsulated vaccine strain 34F2 showed no resistance to challenge
with strain 17JB, which harbours both 110 MDa and 60 MDa plasmids, suggesting that the …
of Bacillus anthracis strains harbouring 110 MDa and/or 60 MDa plasmids. Strains cured of
the 110 MDa or the 60 MDa plasmid were more than 100-fold less virulent to mice than were
the parental strains harbouring these plasmids. Guinea-pigs immunized with plasmid-free
derivatives of the non-encapsulated vaccine strain 34F2 showed no resistance to challenge
with strain 17JB, which harbours both 110 MDa and 60 MDa plasmids, suggesting that the …
Summary
A comparative study was made of the virulence and immunogenicity in mice or guinea pigs of Bacillus anthracis strains harbouring 110 MDa and/or 60 MDa plasmids. Strains cured of the 110 MDa or the 60 MDa plasmid were more than 100-fold less virulent to mice than were the parental strains harbouring these plasmids. Guinea-pigs immunized with plasmid-free derivatives of the non-encapsulated vaccine strain 34F2 showed no resistance to challenge with strain 17JB, which harbours both 110 MDa and 60 MDa plasmids, suggesting that the derivative strains had lost their immunizing ability against anthrax.
Microbiology Research